Section
Hypertrophy Hub
The science and art of building muscle, covering advanced techniques, volume, and exercise selection.

PTs must embrace mental models for lifelong learning and outcomes.
The average physical therapist now encounters 3-5 novel clinical scenarios each week that do not fit textbook descriptions, according to a Clinical Reasoning in PT Practice study.
Elena Pappas· May 30· 3 min

New Drugs Help Patients Lose 60 Pounds and 30% Body Fat
One year ago, Sarah struggled to lose 10 pounds.
Elena Pappas· May 24· 3 min
Analysis & Trends

Best Training Split for Advanced Hypertrophy: How to Choose Between Upper/Lower, PPL, and High-Frequency Options
Elena Pappas · Nov 6

A Strategic Guide to Accessory Lifts for Advanced Lifters
Elena Pappas · Oct 4

Mastering Peak Week: A Comparative Guide to Carb, Water, and Sodium Protocols
Elena Pappas · Oct 2
Explainers

mTOR vs. AMPK: How to Manipulate Load, Volume, and Rest to Bias Your Training Toward Muscle Growth
Elena Pappas · Nov 10

Training for Muscle Fiber Types: What the Evidence Actually Supports
Elena Pappas · Nov 9

Retained Myonuclei: The Cellular Engine Behind Muscle Memory and Faster Regrowth
Elena Pappas · Nov 9

Satellite Cells and the Myonuclear Domain: Why Your Muscle Fibers Can Grow Without New Nuclei
Elena Pappas · Oct 29

Muscle Damage Is Not the Goal: Why Mechanical Tension Drives Hypertrophy and How to Program for It
Elena Pappas · Oct 28

How Satellite Cells Rebuild Your Muscle: The Sequence from Damage to Hypertrophy
Elena Pappas · Oct 29





